Granulocyte Colony Stimulating Factor for Febrile Neutropenic Patients in Pakistan
نویسندگان
چکیده
Febrile neutropenia is a relatively frequent event in cancer patients treated with chemotherapy. In the United States, an estimated 60,000 patients a year are hospitalized for febrile neutropenia and neutropenia related infections (Cagganio et al., 2005). Our single institution data in previous two studies have shown the frequency to be ranging from 10 to 12 per month (Lal et al., 2008; Shaikh et al., 2011). Defined as “A single oral temperature ≥38.0°C for ≥1 hour with a neutrophil count of ≤ 0.5x109/L or a neutrophil count of ≤ 1x109/L which was predicted to fall below ≤ 0.5x109/L (Pettengell et al., 2011), febrile neutropenia is a potentially life threatening situation and requires prompt medical intervention The availability of antibiotics have dramatically improved the outcome at the expense of increased cost (Kuderer et al., 2007) and hence
منابع مشابه
Neutropenic complications in advanced-stage non-Hodgkin's lymphoma: implications for the use of prophylactic recombinant human granulocyte-colony stimulating factor (G-CSF).
OBJECTIVES To determine the incidence of neutropenic complications in patients receiving chemotherapy for advanced-stage non-Hodgkin's lymphoma (NHL), to predict which patients are at high risk for neutropenic complications and to develop an economic model for subsequent testing to assess the potential cost-effectiveness of prophylactic treatment with recombinant human granulocyte-colony stimul...
متن کاملPersonalized medicine and cancer supportive care: appropriate use of colony-stimulating factor support of chemotherapy.
Myelosuppression and neutropenic complications remain major dose-limiting toxicities of cancer chemotherapy resulting in increased morbidity, mortality, and costs ( 1 , 2 ). The major factors that are associated with the risk of mortality from febrile neutropenia (FN) include older age, cancer type and stage, documented infection, bacteremia, sepsis, venous thromboembolism, and the number of se...
متن کاملProphylactic granulocyte colony-stimulating factor in patients receiving dose-intensive cancer chemotherapy: a meta-analysis.
PURPOSE Several studies have evaluated the efficacy of the recombinant colony-stimulating factors in reducing the severity and duration of neutropenia and the risk of infection associated with dose-intensive cancer chemotherapy. We performed a meta-analysis to define better the magnitude of this effect and to assess the generalizability of the results among different diseases and types of treat...
متن کاملComparison of T7- and Lac-Based Systems for the Periplasmic Expression of Human Granulocyte Macrophage Colony Stimulating Factor in Escherichia coli
متن کامل
Monocyte deactivation in neutropenic acute respiratory distress syndrome patients treated with granulocyte colony-stimulating factor
INTRODUCTION In severely neutropenic septic acute respiratory distress syndrome (ARDS) patients, macrophages and monocytes are the last potentially remaining innate immune cells. We have previously shown, however, a deactivation of the alveolar macrophage in neutropenic septic ARDS patients. In the present study, we tried to characterize in vitro monocyte baseline cytokine production and respon...
متن کامل